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RACK1 promotes hepatocellular carcinoma cell survival via CBR1 by suppressing TNF-alpha-induced ROS generation.
Zhou S, Cao H, Zhao Y, Li X, Zhang J, Hou C, Ma Y, Wang Q. Zhou S, et al. Oncol Lett. 2016 Dec;12(6):5303-5308. doi: 10.3892/ol.2016.5339. Epub 2016 Nov 2. Oncol Lett. 2016. PMID: 28105239 Free PMC article.
The present study reports that knockdown of endogenous receptor for activated C kinase 1 (RACK1) increases the intracellular ROS level following TNF-alpha or H(2)O(2) stimulation in human hepatocellular carcinoma (HCC) cells, leading to promotion of cell death. ...T …
The present study reports that knockdown of endogenous receptor for activated C kinase 1 (RACK1) increases the intracellular ROS level follo …
The epigallocatechin gallate derivative Y6 reduces the cardiotoxicity and enhances the efficacy of daunorubicin against human hepatocellular carcinoma by inhibiting carbonyl reductase 1 expression.
Zhou H, Fu LX, Li L, Chen YY, Zhu HQ, Zhou JL, Lv MX, Gan RZ, Zhang XX, Liang G. Zhou H, et al. J Ethnopharmacol. 2020 Oct 28;261:113118. doi: 10.1016/j.jep.2020.113118. Epub 2020 Jul 1. J Ethnopharmacol. 2020. PMID: 32621953
Finally, to obtain further insight into the interactions of Y6 and EGCG with HIF-1alpha and CBR1, we performed a molecular modeling. RESULTS: Y6(10 mug/ml or 55 mg/kg) decreased the expression of HIF-1alpha and CBR1 at both the mRNA and protein levels during combine …
Finally, to obtain further insight into the interactions of Y6 and EGCG with HIF-1alpha and CBR1, we performed a molecular modeling. …
Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells.
Tak E, Lee S, Lee J, Rashid MA, Kim YW, Park JH, Park WS, Shokat KM, Ha J, Kim SS. Tak E, et al. J Hepatol. 2011 Feb;54(2):328-39. doi: 10.1016/j.jhep.2010.06.045. Epub 2010 Sep 17. J Hepatol. 2011. PMID: 21056497
Since human hepatocellular carcinoma (HCC) cells are under oxidative stress in hypoxic conditions, we tested if CBR1 is upregulated by hypoxia inducible factor (HIF)-1alpha, helps tumor growth under hypoxia, and renders chemoresistance to cisplatin and doxoru …
Since human hepatocellular carcinoma (HCC) cells are under oxidative stress in hypoxic conditions, we tested if CBR1 is …
Carbonyl reductase 1 as a novel target of (-)-epigallocatechin gallate against hepatocellular carcinoma.
Huang W, Ding L, Huang Q, Hu H, Liu S, Yang X, Hu X, Dang Y, Shen S, Li J, Ji X, Jiang S, Liu JO, Yu L. Huang W, et al. Hepatology. 2010 Aug;52(2):703-14. doi: 10.1002/hep.23723. Hepatology. 2010. PMID: 20683966
Molecular modeling has revealed that EGCG occupies the active site of CBR1. Furthermore, EGCG specifically enhanced the antitumor activity of DNR against hepatocellular carcinoma SMMC7721 cells expressing high levels of CBR1 and corresponding xenograft …
Molecular modeling has revealed that EGCG occupies the active site of CBR1. Furthermore, EGCG specifically enhanced the antitumor act …
Functional characterization of the promoter of human carbonyl reductase 1 (CBR1). Role of XRE elements in mediating the induction of CBR1 by ligands of the aryl hydrocarbon receptor.
Lakhman SS, Chen X, Gonzalez-Covarrubias V, Schuetz EG, Blanco JG. Lakhman SS, et al. Mol Pharmacol. 2007 Sep;72(3):734-43. doi: 10.1124/mol.107.035550. Epub 2007 Jun 14. Mol Pharmacol. 2007. PMID: 17569794
Furthermore, we tested whether the potent AHR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced Cbr1 expression in Ahr(+/-) and Ahr(-/-) mice. TCDD induced hepatic Cbr1 mRNA (TCDD, 2-fold) and Cbr1 protein levels (TCDD, 2-fold) in Ahr(+/-) mice compar …
Furthermore, we tested whether the potent AHR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced Cbr1 expression in Ahr(+/-) a …
Differential changes in the pharmacokinetics of doxorubicin in diethylnitrosamine-induced hepatocarcinoma model rats.
Pan J, Lu Y, Zhang S, Li Y, Sun J, Liu HC, Gong Z, Huang J, Cao C, Wang Y, Li Y, Liu T. Pan J, et al. Xenobiotica. 2020 Oct;50(10):1251-1257. doi: 10.1080/00498254.2020.1765049. Epub 2020 May 13. Xenobiotica. 2020. PMID: 32375563
Hepatocellular carcinoma (HCC) is a malignancy of liver cells. Recent studies have shown that HCC patients often have changes in the activities of transporters and metabolic enzymes, which can considerably affect drug pharmacokinetics and lead to drug toxicity. ...T …
Hepatocellular carcinoma (HCC) is a malignancy of liver cells. Recent studies have shown that HCC patients often have changes …
Evaluation of the Effect of Uremic Serum on Hepatic Reductase Functional Expression.
Alshogran OY, Al-Obaidi EAF, Al-Husein BA, Oweis AO. Alshogran OY, et al. Drug Metab Lett. 2018;12(1):75-81. doi: 10.2174/1872312812666180416154436. Drug Metab Lett. 2018. PMID: 29658443
This study evaluated the influence of uremic serum on the expression and activity of reductase enzymes. METHODS: Human hepatocellular carcinoma cells (HepG2) were incubated with 5% pooled serum collected from patients with hemodialysis (pre- and post-dialysis sessio …
This study evaluated the influence of uremic serum on the expression and activity of reductase enzymes. METHODS: Human hepatocellular …